We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
Read More
8
EPA lowers heart rhythm problems
Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.
We investigated how eicosapentaenoic acid (EPA) affects heart rhythm, particularly in the context of high-fat diets. In our study, mice were divided into two groups: one received a high-fat diet, while the other’s diet was supplemented with EPA for eight weeks.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
Read More
9
High-dose omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Read More
Most Useful Reviews
9
Cholesterol reduction
4 people found this helpful
I purchased this Omega 3 for my husband due to his atherosclerosis and heart attack. Remarkably, his cholesterol dropped to 3 while taking it alongside his statin medications.
Read More
9
Best quality omega
3 people found this helpful
This is my consistent choice for Omega. It undoubtedly benefits heart function, reduces cholesterol, improves hair condition, and lessens chronic inflammation. The product offers the best quality and optimal dosage. I highly recommend it to others for use.
Read More
9
High-quality omega
2 people found this helpful
Prescribed by my cardiologist, I chose this omega with a high EPA content to effectively support my heart's blood vessels. It's derived from anchovies, avoiding heavy metals. This large dosage makes it the best choice for me.
We analyzed the impact of different fatty acid-derived acylcarnitines on heart health. The study found that saturated and monounsaturated acylcarnitines, especially trans-elaidoylcarnitine, significantly impaired heart function and mitochondrial activity, leading to cardiotoxicity.
In contrast, omega-3-derived acylcarnitines, like eicosapentaenoylcarnitine and docosahexaenoylcarnitine, were found to be safe, having little to no negative effect on heart function and cell viability. Overall, this research suggests that omega-3 fatty acids may be a safer option for those facing cardiac challenges.
Read More
9
High-dose omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Read More
9
Omega-3 reduces heart disease risk
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
Read More
9
Omega-3 benefits African Americans’ heart health
Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation.
We observed that the role of omega-3 fatty acids in heart health showed promising results specifically for African Americans. By comparing matched groups from the VITAL trial, we found that omega-3 supplementation significantly reduced the risk of myocardial infarction in African Americans, while no such benefit was seen in non-Hispanic whites.
This suggests that genetic or lifestyle factors may influence the effectiveness of these supplements. Our findings highlight the importance of further research to better understand how race affects responses to omega-3 supplementation.
Read More
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
I purchased this Omega 3 for my husband due to his atherosclerosis and heart attack. Remarkably, his cholesterol dropped to 3 while taking it alongside his statin medications.
Read More
9
Best quality omega
3 people found this helpful
This is my consistent choice for Omega. It undoubtedly benefits heart function, reduces cholesterol, improves hair condition, and lessens chronic inflammation. The product offers the best quality and optimal dosage. I highly recommend it to others for use.
Read More
9
High-quality omega
2 people found this helpful
Prescribed by my cardiologist, I chose this omega with a high EPA content to effectively support my heart's blood vessels. It's derived from anchovies, avoiding heavy metals. This large dosage makes it the best choice for me.
Read More
9
Enhances cognitive ability
1 people found this helpful
Pure Omega 3 fish oil improves cardiovascular health by lowering blood lipids, reducing the risk of heart disease, and enhancing cognitive function, memory, and learning abilities. It also promotes joint health, boosts immunity, and has anti-inflammatory effects, making it a vital supplement for holistic health.
Read More
9
Exceptional heart health
1 people found this helpful
I am extremely satisfied with the Omega supplements I purchased. I have seen substantial improvements in my heart health and overall well-being since incorporating these supplements into my daily routine. The benefits for heart health are evident, and I appreciate the high-quality ingredients. I highly recommend them to anyone wanting to support their heart health with a reliable and premium product.
Heart disease refers to a range of conditions that affect the heart's function and overall health. This umbrella term includes various cardiovascular issues such as coronary artery disease, which is caused by the buildup of plaque in the arteries; heart rhythm problems (arrhythmias); and heart defects present at birth (congenital heart defects). Additionally, heart disease encompasses conditions related to the heart muscle, such as cardiomyopathy, and the heart's valves, which might not open or close properly. The effects of heart disease can be significant, impacting not only physical health but also quality of life, making prevention and timely medical intervention crucial.
Several risk factors contribute to the development of heart disease, including high blood pressure, high cholesterol levels, diabetes, obesity, poor diet, physical inactivity, and smoking. Genetics also play a role, as heart disease can run in families. To mitigate the risks, healthcare professionals typically recommend lifestyle changes such as adopting a heart-healthy diet, engaging in regular physical activity, and avoiding tobacco use. For those already diagnosed with heart disease, treatment options can vary widely, ranging from lifestyle modifications to medications and, in severe cases, surgical interventions. Understanding the nature of heart disease and its risk factors is an essential step toward prevention and effective management.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has long been touted for its potential heart health benefits, and there is a growing body of research that supports its positive role in cardiovascular health. Omega-3 fatty acids—primarily EPA and DHA, found in fish oil—are known to help reduce inflammation, lower triglyceride levels, and may improve arterial function. Studies suggest that regular consumption of omega-3s can lead to a modest reduction in the risk of heart disease, particularly for those with existing cardiovascular conditions or elevated risk factors.
However, it's essential to note that while omega-3 fish oil can be beneficial, it should not be seen as a standalone treatment for heart disease. It's most effective when used in conjunction with a heart-healthy lifestyle, which includes a balanced diet, regular exercise, and other preventative measures. As always, it's recommended to consult with a healthcare professional before starting any new supplement regimen, especially for individuals with existing health issues or those on medication. Keep in mind that the effectiveness can vary from person to person, depending on individual health profiles and dietary needs.
Based on user reviews of Omega-3 supplements, the timeline for seeing results can vary significantly among individuals. Some users report noticeable benefits within just a week of starting the supplement, such as improved heart function and lower cholesterol levels Read Review. Others mention experiencing substantial improvements in heart health and overall well-being in a short period after incorporating these supplements into their daily routine Read Review.
However, certain users suggest that it might take longer for the effects to become evident, particularly in terms of long-term heart health and maintenance Read Review. Many users emphasize the importance of consistency in taking the supplements for optimal results, recommending daily use to fully realize the benefits, which often include improvements in cholesterol, inflammation reduction, and enhanced overall health Read Review. Overall, while some users feel a difference quickly, others emphasize the gradual accumulation of benefits over time.
The evidence surrounding omega-3 fatty acid supplementation, particularly eicosapentaenoic acid (EPA), showcases significant promise in supporting heart health and managing heart disease. Numerous studies have highlighted how EPA supplementation may reduce the risk of serious cardiovascular events. For instance, the REDUCE-IT trial demonstrated that individuals taking icosapent ethyl, a specific form of EPA, had notably fewer cardiovascular events compared to those on a placebo, which was significant even among patients with well-controlled cholesterol levels ([5]). Additionally, a comprehensive analysis involving 310,955 participants revealed that higher omega-3 fatty acid levels, including EPA, were associated with a lower risk of sudden cardiac death and cardiovascular mortality ([19]).
However, not all findings are uniformly supportive, as high doses of EPA might increase the risk of arrhythmias like atrial fibrillation in some cases ([7]). Furthermore, there are indications that patients with diabetes might experience less favorable outcomes when supplemented with omega-3 fatty acids, necessitating a more tailored approach depending on individual health profiles ([27]). Overall, while the body of research generally supports the use of omega-3 supplements for heart health, individuals should consult healthcare professionals to evaluate potential benefits and risks specifically tailored to their health circumstances.
Users report a variety of significant improvements in symptoms after incorporating Omega-3 supplements into their daily routines. Many individuals have noted substantial benefits for heart health, such as reduced cholesterol levels and improved cardiovascular function. For instance, one reviewer mentioned their husband's cholesterol dropped to optimal levels while on Omega-3 alongside statin medications Read Review. Others have highlighted enhancements in overall well-being, stressing that these supplements have helped alleviate conditions like chronic inflammation and musculoskeletal pain, further corroborated by a user who experienced relief from pain after switching to a specific Omega-3 product Read Review.
In addition to heart health, users have experienced cognitive benefits, with several noting improvements in memory and concentration. For example, one consumer praised the Omega-3 supplements for enhancing their cognitive functions and overall mental health Read Review. Furthermore, there are anecdotal reports of improvements in hair and skin health, with users appreciating the quality of the product and its minimal adverse taste Read Review. Overall, while individual results can vary, many users express satisfaction and highlight these supplements as beneficial for both physical and mental health.
Users frequently report positive outcomes when combining Omega-3 supplements with other heart medications, particularly statins. One reviewer noted their husband's cholesterol dramatically decreased while taking Omega-3 in tandem with prescribed statin medication, highlighting the potential synergistic effects for heart health Read Review. Another user emphasized consistent use of Omega-3 as part of their regimen, which, according to their doctor, contributed significantly to maintaining healthy systolic blood pressure and heart function Read Review.
Additionally, a considerable number of users report overall improvements in heart health when incorporating Omega-3 into their daily routine, sometimes alongside other supplements or medications. One individual described Omega-3's benefits for lowering bad cholesterol levels, enhancing cardiovascular health, and reducing inflammation Read Review. Furthermore, another reviewer stated that the quality of the Omega-3 supplement helped normalize their cholesterol while also targeting inflammation and promoting healthier skin and hair, demonstrating the comprehensive impact on well-being beyond just heart health Read Review. Overall, many users appear satisfied with the results of combining Omega-3 with other treatment protocols aimed at supporting heart health.
Research suggests that the optimal dose of Omega-3 fish oil for treating heart disease is between 2000 and 4000 mg daily. A study analyzing multiple randomized controlled trials with over 9,000 participants found that this dosage significantly improved heart function over at least a year of treatment [6]. Furthermore, patients taking icosapent ethyl, a specific formulation of Omega-3, also experienced reduced cardiovascular events regardless of their baseline cholesterols, underscoring the potential benefits of high Omega-3 intake in heart disease management [5].
It's important to note that while higher doses can yield substantial benefits, individual responses may vary, and consulting with a healthcare provider before beginning any supplementation regimen is essential. Monitoring and adjusting the intake based on personal health conditions and risk factors will help maximize the benefits while minimizing any potential risks associated with high-dose supplementation.
7.5
Maintains vascular health
This excellent fish oil contains omega-3, particularly beneficial for those over 50. It comes in a package of 120 pieces, with noticeable benefits after just a week. It effectively reduces cholesterol, improves hair shine, alleviates inflammation, and helps maintain heart function.
9
Exceptional heart health
1 people found this helpful
I am extremely satisfied with the Omega supplements I purchased. I have seen substantial improvements in my heart health and overall well-being since incorporating these supplements into my daily routine. The benefits for heart health are evident, and I appreciate the high-quality ingredients. I highly recommend them to anyone wanting to support their heart health with a reliable and premium product.
7.5
Maintained heart health
2 people found this helpful
I take this every morning for heart health. After using it for several years, my systolic BP remains under 130 at 72 years old, with no heart-related issues. I’m unsure if it's solely due to the fish oil capsules, but I intend to continue using them as a preventive measure.
7.5
Reduces inflammation
1 people found this helpful
Doctor's Best Pure & Clean Omega-3 Fish Oil is renowned for its high-quality ingredients. Users note its effectiveness in enhancing heart health and reducing inflammation. The omega-3 fatty acids positively impact cholesterol levels and hair health. Praised for its negligible fishy taste and easy packaging, it's a top choice for effective omega-3 supplementation.
9
Cholesterol reduction
4 people found this helpful
I purchased this Omega 3 for my husband due to his atherosclerosis and heart attack. Remarkably, his cholesterol dropped to 3 while taking it alongside his statin medications.
7.5
Improves sleep quality
1 people found this helpful
I have used various omega 3 supplements for normalising cholesterol and heart health but none compares to this product. Just one capsule makes a noticeable difference. The quality is outstanding, and I experienced impressive benefits, such as relief from muscle and joint pain and improved sleep, making it ideal for my age and dietary needs.
9
Important for heart
6 people found this helpful
Omega 3 is an essential and significant supplement for overall health, helping to enhance brain function, concentration, and heart protection, as well as reducing harmful cholesterol. It also combats depression and aids skin and hair health while reducing inflammation. The quality and ingredients are excellent.
9
Hair and skin improvement
This product's quality is exceptional. It's high in omega-3, beneficial for heart, brain, hair health, and skin elasticity. It tightens skin and lowers cholesterol without unpleasant taste. I highly recommend it, thanks iHerb! 🩷
9
Enhances cognitive ability
1 people found this helpful
Pure Omega 3 fish oil improves cardiovascular health by lowering blood lipids, reducing the risk of heart disease, and enhancing cognitive function, memory, and learning abilities. It also promotes joint health, boosts immunity, and has anti-inflammatory effects, making it a vital supplement for holistic health.
7.5
Rich in antioxidants
6 people found this helpful
A highly effective nutritional supplement with excellent ingredients and quality. It is rich in antioxidants and essential for heart health, as well as reducing inflammation in the digestive system, lowering cholesterol, and benefitting skin, eyes, and hair. It's also useful against viruses, bacteria, and germs. Overall, an indispensable source of omega.
8
Omega-3 reduces heart disease risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We explored the effectiveness of icosapent ethyl, a form of omega-3 fish oil, in lowering heart disease rates among high-risk patients with varying cholesterol levels.
In a clinical trial with statin-treated individuals who had elevated triglycerides, it was found that those taking icosapent ethyl experienced significantly fewer cardiovascular events compared to those on a placebo.
Notably, this benefit was seen regardless of their baseline low-density lipoprotein cholesterol (LDL-C) levels, indicating positive outcomes even for patients with well-controlled cholesterol.
8
Eicosapentaenoic Acid reduces heart risks
Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis.
We evaluated the impact of eicosapentaenoic acid (EPA) on heart disease, specifically focusing on its potential to reduce the risk of sudden cardiac death (SCD) and cardiovascular mortality (CVD mortality). Through a systematic review and meta-analysis, we gathered insights from 10 prospective cohort studies involving a total of 310,955 participants over an average follow-up period of 8.7 years.
Our analysis revealed that higher levels of omega-3 fatty acids, including EPA, in the blood were associated with a lower risk of both SCD and CVD mortality. Specifically, we found that individuals with high circulating levels of EPA and other omega-3s had a significantly reduced hazard ratio of 0.55 for SCD compared to those with lower levels. This suggests a protective effect linked to increased EPA intake.
Furthermore, our sub-analysis indicated that higher percentages of EPA and another omega-3 called DHA in the blood also correlated with a reduced risk of adverse cardiac events. These findings highlight the promising role of EPA as a beneficial component in cardiovascular health strategies.
Overall, the evidence suggests that increasing our intake of EPA could serve as an effective measure to lessen the incidence of serious heart-related issues, making it a topic worth considering in future dietary recommendations.
7
Omega-3 may reduce certain arrhythmias
The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial.
We conducted a randomized clinical trial with 74 patients recovering from acute coronary syndrome (ACS) to see if Omega-3 supplementation could help reduce harmful heart rhythms. Participants received either a daily dose of 1 gram of Omega-3 or a placebo for five days, with their heart rhythms closely monitored using ECGs.
Our findings showed that Omega-3 fatty acids could potentially help manage arrhythmias, especially atrial fibrillation and some types of contractions. However, the treatment had minimal impact on more severe arrhythmias like ventricular tachycardia and fibrillation, indicating that more research is needed in this area.
4
CAC progression in diabetic patients
The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial.
We explored the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the progression of coronary artery calcium (CAC) in individuals with heart disease. In a randomized trial involving 242 subjects already on statin therapy, half received daily doses of both EPA and DHA, while the other half did not receive these supplements.
Our findings indicated a notable interaction between diabetes status and the effects of these supplements. Specifically, subjects with diabetes who took EPA and DHA experienced a greater increase in CAC scores compared to those with diabetes in the control group. This suggests that for individuals with diabetes, the use of these omega-3 fatty acids might not be beneficial, as they witnessed significant progression in heart disease markers over a 30-month period.
Meanwhile, we observed no significant difference in CAC progression between the treatment and control groups among those without diabetes. This raises questions about the complex role of EPA and DHA in heart health, particularly in the context of diabetes. Further research is needed to clarify whether this CAC progression indicates worsening disease or if it reflects a stabilization of existing plaques.
9
High-dose omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
References
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Xu J, Peng T, Kong L, Wei N. A global analysis of the burden of ischemic heart disease attributable to diet low in ω-3 fatty acids between 1990 and 2021. BMC Cardiovasc Disord. 2025;25:188. 10.1186/s12872-025-04620-z
Horii K, Ono K, Sumi T, Higashihara M, Zaima N, et al. Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice. J Physiol Sci. 2025;75:100014. 10.1016/j.jphyss.2025.100014
Dawczynski C, Drobner T, Weidauer T, Schlattmann P, Kiehntopf M, et al. Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study. Lipids Health Dis. 2025;24:88. 10.1186/s12944-025-02500-1
Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. 10.1515/jcim-2024-0427
Wang Y, Wu G, Wang Y, Rehman A, Yu L, et al. Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases. Food Chem. 2025;470:142498. 10.1016/j.foodchem.2024.142498
Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. 10.1016/j.mayocp.2024.08.007
Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. 10.1017/S0007114524002708
Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
Ryuno Y, Kobayashi JI, Fujimoto Y, Dotare T, Matsue Y, et al. Effect of an Enteral Formula Enriched With ω-3 Fatty Acids, Carnitine, and Vitamin D on Body Weight, Heart Weight, and Blood Biochemical Parameters in a Dahl Rat Heart Failure Model. J Cardiovasc Pharmacol. 2024;84:590. 10.1097/FJC.0000000000001637
Sun S, Hara A, Johnstone L, Hallmark B, Watkins JC, et al. Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation. Nutrients. 2024;16. 10.3390/nu16172933
Ahmadi M, Askari VR, Shahri B, Mousavi Noghab SM, Jarahi L, et al. Omega-3 fatty acids effectively mitigate high-sensitivity C-reactive protein (hs-CRP) biomarker of inflammation in acute myocardial infarction patients: a randomized, double-blind, placebo-controlled clinical trial. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:881. 10.1007/s00210-024-03330-1
Chen HC, Tai CJ, Huang JY, Kuo TA, Huang YD, et al. Associations of fish oil with cardiovascular disease events: results from the Taiwan longitudinal study in aging. BMC Public Health. 2024;24:1979. 10.1186/s12889-024-19512-8
Yu Y, Gao M, Xu H. Ginger Extract and Omega-3 Fatty Acids Supplementation: A Promising Strategy to Improve Diabetic Cardiomyopathy. Physiol Res. 2024;73:351.
Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.028
Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. 10.1007/s40261-024-01417-4
Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. 10.3390/jcm14010026
Capece U, Gugliandolo S, Morciano C, Avolio A, Splendore A, et al. Erythrocyte Membrane Fluidity and Omega-3 Fatty Acid Intake: Current Outlook and Perspectives for a Novel, Nutritionally Modifiable Cardiovascular Risk Factor. Nutrients. 2024;16. 10.3390/nu16244318
Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. 10.7759/cureus.73417
O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. 10.1016/j.pcad.2024.11.003
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. 10.3389/fnut.2024.1423228
Amangurbanova M, Daher R, Asbeutah AA, Vemuri B, Mirza H, et al. Higher epicardial adipose tissue volume is associated with higher coronary fatty plaque volume and is regulated by waist circumference but not EPA+DHA supplementation. J Clin Lipidol. 2024;18:e773. 10.1016/j.jacl.2024.06.006
Kumakura H, Funada R, Matsuo Y, Iwasaki T, Nakashima K, et al. Eicosapentaenoic Acid Level Predicts Long-Term Survival and Cardiovascular or Limb Event in Peripheral Arterial Disease. Ann Vasc Dis. 2024;17:135. 10.3400/avd.oa.23-00079
Xiao Y, Chen Y, Pietzner A, Elbelt U, Fan Z, et al. Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies. Nutrients. 2024;16. 10.3390/nu16111610
Asbeutah AA, Daher R, Malik A, Hariri E, Alfaddagh A, et al. The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial. Am J Cardiol. 2024;225:98. 10.1016/j.amjcard.2024.06.001
Sudo Y, Morimoto T, Tsushima R, Oka A, Sogo M, et al. Eicosapentaenoic Acid and the Outcomes in Older Patients Undergoing Atrial Fibrillation Ablation. J Am Heart Assoc. 2024;13:e033969. 10.1161/JAHA.123.033969
Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150:425. 10.1161/CIRCULATIONAHA.123.065520